These emerging AI technologies, specifically supervised and unsupervised machine learning models, have allowed us to identify for the first time in new humanized knock-in animals, models of Alzheimer’s disease, a robust identification of the disease phenotype. This is very important because it allows us to use these models for drug development. We have a second finding in a group of animals that are transgenic models of Alzheimer’s disease, these animals have a pretty overt manifestation of disease in both their biology and in their behavior...
These emerging AI technologies, specifically supervised and unsupervised machine learning models, have allowed us to identify for the first time in new humanized knock-in animals, models of Alzheimer’s disease, a robust identification of the disease phenotype. This is very important because it allows us to use these models for drug development. We have a second finding in a group of animals that are transgenic models of Alzheimer’s disease, these animals have a pretty overt manifestation of disease in both their biology and in their behavior. And alongside those diseased animals, we studied a set of animals that have a protective genetic intervention that interrupts an inflammatory pathway that’s associated with leaky blood vessels in the brain and how those blood proteins would stress out the microglial cells who then go on to stress out the neurons. By interrupting the inflammatory pathway, we’re able to actually prevent many behavioral manifestations of disease in these bigenic animals.
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