Celia Oreja-Guevara, MD, PhD, University Hospital San Carlos, Madrid, Spain, discusses the latest strategies for multiple sclerosis (MS) management. In recent years, the field has shifted towards an early and aggressive approach to treatment. Newer and more efficacious agents are used as early as possible after diagnosis, rather than using less aggressive treatments first line and escalating as needed. Dr Oreja-Guevara also comments on how to navigate the crowded therapeutic market, noting that all available information should be used to determine the best treatment option for an individual patient. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.