Sleep Europe 2026 | Long-term melatonin safety in insomnia: how clinicians should interpret observational signals

Alessandro Colitta, MD, University of Pisa, Pisa, Italy, discusses a recent commentary on melatonin safety in adults with insomnia, cautioning clinicians to interpret observational safety signals carefully. He highlights that one cited study did not account for confounding factors, such as severe insomnia phenotypes with shorter sleep duration and higher autonomic activation, and that single case reports lack the scientific strength to warrant a warning on melatonin use. Dr Colitta highlights the need for large observational studies addressing both potential long-term harms of melatonin and these confounders. This interview took place at Sleep Europe 2026 in Maastricht, the Netherlands.

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