EAN 2026 | Could identifying myelin damage in patients with presymptomatic MS enable earlier intervention?
Anthony Traboulsee, MD, University of British Columbia, Vancouver, Canada, discusses research investigating the earliest pathological changes in multiple sclerosis (MS). Prof. Traboulsee highlights findings showing that patients with radiologically isolated syndrome (RIS) who have damage throughout the myelin have reduced cognitive performance, indicating an early window for diagnosis and intervention. This interview took place at the 12th Congress of the European Academy of Neurology (EAN) in Geneva, Switzerland.
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Transcript
One of the areas of interest is trying to identify people as early as possible who might have multiple sclerosis. And that reflects a change in the diagnostic criteria where people with MRI that is suggestive of MS but no symptoms of MS can now be diagnosed with MS. And part of our study was to explore do they have evidence of diffuse injury, diffuse injury to the myelin throughout the brain that might be affecting their cognitive performance even before they have actual symptoms of MS...
One of the areas of interest is trying to identify people as early as possible who might have multiple sclerosis. And that reflects a change in the diagnostic criteria where people with MRI that is suggestive of MS but no symptoms of MS can now be diagnosed with MS. And part of our study was to explore do they have evidence of diffuse injury, diffuse injury to the myelin throughout the brain that might be affecting their cognitive performance even before they have actual symptoms of MS. And in fact we do find that there are some patients with presymptomatic MS called radiologic isolated syndrome that actually have damage throughout the myelin and they don’t perform cognitively as well as those without that damage. And this really gives us the earliest window into the evolution of damage in multiple sclerosis and the earliest opportunity to treat prevent that damage and start driving remyelination repair.
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