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AAN 2024 | The microbiome in Parkinson’s disease onset and exacerbation

Valentina Leta, MD, King’s College Hospital & King’s College London, London, UK, provides a background of gut health in Parkinson’s disease (PD) and outlines what is known about the role of the gut microbiome in disease onset and exacerbation. Some degree of gastrointestinal (GI) dysfunction is seen in all patients with PD, and clinical manifestations of GI dysfunction (including dysphagia, delayed gastric emptying, and constipation) can precede the onset of motor symptoms. Several mechanisms have been identified that may explain these disturbances, including alteration of the gut microbiome. This provides the rationale for the use of microbiome-modulating interventions, such as probiotics and fecal microbiota transplantation, in the treatment of PD. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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