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AAN 2025 | REM sleep behavior disorder as early synuclein-related disease
Ambra Stefani, MD, PhD, Medical University of Innsbruck, Innsbruck, Austria, discusses the current understanding of REM sleep behavior disorder, highlighting its association with early alpha-synucleinopathy and the need for a comprehensive approach to address its various aspects, including clinical, neuroimaging, genetic, and pathophysiological perspectives. This interview took place at the 77th American Academy of Neurology (AAN) Annual Meeting in San Diego, CA.
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Transcript
This was also a review article together with several experts on REM sleep behavior disorder addressing really different aspects of the disease. So from the clinical point of view to neuroimaging, genetic aspects, neurophysiology and so on and also the pathophysiology of the disease to try to put together an overview of how REM sleep behavior disorder is considered and it’s been demonstrated to be an early alpha-synucleinopathy disease and yes, just to try to put this disease in a context...
This was also a review article together with several experts on REM sleep behavior disorder addressing really different aspects of the disease. So from the clinical point of view to neuroimaging, genetic aspects, neurophysiology and so on and also the pathophysiology of the disease to try to put together an overview of how REM sleep behavior disorder is considered and it’s been demonstrated to be an early alpha-synucleinopathy disease and yes, just to try to put this disease in a context.
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