ECTRIMS 2023 | Understanding the role of the complement system in MS

Francesca Gilli, PhD, Dartmouth College, Hanover, NH, discusses the role of the complement system, a vital component of the innate immune system, in multiple sclerosis (MS) and other neurodegenerative diseases. The complement system consists of 15 different proteins that work together to clear pathogens and damaged cells, promote inflammation, and attack pathogen membranes. While complement activation is beneficial in fighting off viral and bacterial pathogens, in certain cases, such as MS, it can become overactivated and lead to excessive inflammation, cell death, and phagocytosis. Studies have revealed that there is an accumulation and overactivation of the complement system in lesions of MS patients. Understanding the involvement of the complement system in neurodegenerative diseases may provide valuable insights for developing targeted therapies. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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