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ECTRIMS 2021 | Inflammatory microRNA levels associate with worse disability in MS

Inflammatory microRNAs are emerging as potential promising diagnostic/prognostic biomarkers in multiple sclerosis (MS). Bárbara Guerra Leal, PhD, University of Porto, Porto, Portugal, shares the findings of a multicenter study looking at the diagnostic/prognostic ability of miR-26a and miR-145 in MS. miR levels were measured in the serum of 116 patients and 63 healthy controls. Overall, it was observed that the circulating levels of miR-26a and miR-145 did not differ between the patient and control group. However, lower miR-26a levels were associated with worse disability, particularly in smokers. Additionally, when HLA-DRB1*15-positive patients were investigated in isolation, these individuals showed lower miR-26a levels and higher disability scores. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) congress 2021.