EAN 2026 | The revolutionary impact of CGRP-targeting therapies on migraine treatment

Really, they have constituted a real revolution for migraine treatment, though they are peripheral, and we had this question, but we think that they could work the same, as they could change the pain-related areas, and so they can also help the migraine brain to really prevent migraine and also to change the outcome of the disease. Our main question is about the block of CGRP, a unique neurotransmitter, how this can change the complete scenario of migraine, which is very complex. But now, in real-life studies, we are understanding that it is possible. It is possible because, with a very strong antinociceptive action, we can really have also a reset and reversion of main central abnormalities which underlie migraine. We had an incredible number of patients with a good response to such drugs. A minority of patients did not, and they are for refractory migraine, and they are a very outstanding problem for us. We are trying also to understand why this could happen and how also to resolve this matter, and we think that integrated therapies with also psychological support and also targeting probably other neurotransmitters of inflammation, we could obtain much more results. But now, we are happy also with the present results we had in the last five years of migraine. I think that we had, in the last years, a real revolution in migraine treatment, and it was a very good thing for patients and also for physicians, and we think that it is the ideal way to go through this for a better understanding of migraine and migraine management as well.

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