ISC 2023 | Adjunctive therapies to improve outcomes after thrombectomy for ischemic stroke

Xiaochuan Huo, MD, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, shares his thoughts on ongoing efforts to improve outcomes after endovascular thrombectomy for acute ischemic stroke. Thrombectomy is the most effective treatment for ischemic stroke. Despite this, only ~50% of patients undergoing thrombectomy achieve functional independence (mRS 0-2) at 90 days. In some cases, thrombectomy may be unsuccessful but in others, patients do not experience a good clinical long-term outcome despite successful recanalization, known as futile recanalization. Dr Huo comments on strategies that could be combined with thrombectomy to improve outcomes. For example, intra-arterial thrombolysis therapy after thrombectomy is being assessed as a way of improving tissue perfusion at the microvascular level. Neuroprotective agents given prior to endovascular treatment, such as ApTOLL, are also being studied. This interview took place during the International Stroke Conference (ISC) 2023 in Dallas, TX.

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