EAN 2025 | Incorporating biomarker testing into the diagnostic workup for patients with overlapping features
Anastasia Bougea, PhD, National and Kapodistrian University of Athens, Athens, Greece, emphasizes the importance of a detailed clinical history and neurological examination in the diagnostic workup of patients with overlapping features. Dr Bougea advises neurologists to use a combination of clinical tools, including examination, history, laboratory tests, and biomarkers, to make informed decisions. This interview took place at the 11th Congress of the European Academy of Neurology (EAN 2025) in Helsinki, Finland.
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Transcript
Nowadays, biomarkers are many times incorporated in clinical practice, but I have to say that this is not the norm because there are many problems and financial problems that we have to overcome. And of course the evidence-based level which is not definitely specific. So I have to say that the clinical neurologist in his everyday clinical practice should take a very, very detailed clinical history, a very detailed neurological examination...
Nowadays, biomarkers are many times incorporated in clinical practice, but I have to say that this is not the norm because there are many problems and financial problems that we have to overcome. And of course the evidence-based level which is not definitely specific. So I have to say that the clinical neurologist in his everyday clinical practice should take a very, very detailed clinical history, a very detailed neurological examination. This will never be substituted by statistical tools and mathematical models; these are his eyes and his hands, the most important tools of neurologists. So, examination, history, clinical history, ask for the appropriate tests and laboratory tests, magnetic resonance testing, and then a CSF sample. Take a CSF sample, have a blood specimen, keep these specimens for analysis of biomarkers. Biomarkers are going to be an adjuvant test that’s going to help the neurologist with his first impression. He has to use all of them, neurological examination, clinical history, laboratory tests, and biomarkers, all together to make his final decision.
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