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AD/PD 2021 | Late-onset depression as a risk factor for prodromal PD

Anette Schrag, FRCP, PhD, University College London, London, UK, describes a study evaluating late-onset depression (LOD) as a potential risk factor for prodromal Parkinson’s disease (PD). Patients with first onset of depression diagnosed after the age of 55 years old were recruited in to the study and underwent clinical assessment of motor and non-motor symptoms of PD, as well as dopamine transporter and magnetic resonance imaging. The results indicated that LOD is associated with an increased rate of motor and non-motor features of prodromal PD and abnormal dopamine transporter imaging. This interview took place during the AD/PD™ 2021 conference.


Prof. Schrag has received consultancy fees from Roche, Biogen and Abbvie and grant support from GE Healthcare in the last 12 months.