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ECTRIMS 2023 | NEXT-MS trial: natalizumab personalized extended interval dosing

Alyssa Toorop, MD, PhD, Amsterdam University Medical Centers, Amsterdam, The Netherlands, discusses the NEXT-MS trial (NCT04225312) focused on personalized extended interval dosing of natalizumab in relapsing-remitting multiple sclerosis (MS). Although 94% of patients on standard four-week intervals retain high drug concentrations, research suggests extended interval dosing could maintain therapeutic effects, reduce potential side effects, and curtail healthcare costs. The NEXT-MS study aimed to validate personalized dosing efficacy by monitoring drug concentrations. Conducted across 21 Dutch hospitals, the study had participants in three groups, with a focus on target drug concentrations of 10 or 5 micrograms per milliliter. Results revealed that personalized dosing was preferred by 84% of participants and showed no increased disease activity. Moreover, a lower drug concentration target of 5 micrograms per milliliter was found efficacious. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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The NEXT-MS trial was funded by the Dutch MS Research Foundation, the Brain Foundation Netherlands, and Innovation Funds Healthcare insurers. The funding sources had no involvement in the execution of the study.