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ISA 2022 | Targeting glycation as a potential therapeutic avenue in Parkinson’s disease

Daniel Otzen, PhD, Aarhus University, Aarhus, Denmark, comments on the role of glycation in Parkinson’s disease (PD) and explains how this process could be targeted to treat this disease. Prof. Otzen explains that whilst α-synuclein glycation can reduce fibril formation, it can also lead to the formation of smaller cytotoxic oligomers. However, by finding the optimal number of post-translational modifications (PTMs), it is possible to effectively inhibit fibril elongation, thus opening a new therapeutic avenue for protein aggregation disorders. This interview took place at the 2022 International Symposium on Amyloidosis (ISA) held in Heidelberg, Germany.

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