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ECTRIMS 2023 | White matter disconnectivity and inflammation in MS patients with PRLs

Ceren Tozlu, PhD, Weill Cornell Medicine, New York City, NY, discusses the study of paramagnetic rim lesions (PRLs) in multiple sclerosis (MS) patients. PRLs are characterized by iron-laden macrophages at the MS lesion’s rim, indicative of increased inflammation and are associated with greater motor and cognitive impairments. The research focused on discerning the impact of these lesions on the white matter streamlines in relation to inflammatory activity. Utilizing tools like quantitative susceptibility mapping and network modification, the study distinguished the level of disconnectivity in white matter due to MS lesions. Findings revealed that MS patients with at least one PRL exhibit elevated inflammatory activity in both healthy and highly damaged voxels when compared to those without PRLs. Additionally, inflammation was found to be significantly correlated with disability only in the presence of PRLs. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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