AAN 2024 | 3D visualization of disease burden in multiple sclerosis

Stephen Krieger, MD, FAAN, Icahn School of Medicine at Mount Sinai, New York, NY, presents a novel visualization of the topographical model of multiple sclerosis (MS) using 3D rendering of quantified MRI. This model has been termed the ‘leaky swimming pool’ model by some, as it represents the pool of reserve which allows patients to compensate for disease burden (i.e., lesions), with some lesions under the surface either remaining under the clinical threshold or manifesting over time. Dr Krieger employed a novel 3D imaging technique to extract information on lesion burden from different areas of interest in the brain, and this data was subsequently used to map lesion burden on a topographical model. This model allows for a 3D visualization of an individual’s MS disease burden and will be further refined in the future with the addition of brain volumes to visualize reserve. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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