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AAN 2023 | MOG-IgA characterizes a subgroup of patients with central nervous system demyelination

Anne-Katrin Pröbstel, MD, University Hospital of Basel, University of Basel, Basel, Switzerland, describes the results of a study designed to assess the frequency of myelin oligodendrocyte glycoprotein (MOG) IgA in patients with central nervous system demyelination and link this to clinical phenotypes. The study screened for MOG-IgA, IgG, and IgM in 1339 patients with demyelinating diseases, and 110 healthy controls. Of the 18 patients with isolated MOG-IgA, 6% had double seronegative NMOSD, 2% had ‘other’ demyelinating diseases, and 1% had multiple sclerosis (MS), showing a strong link to neuromyelitis optica spectrum disorder (NMOSD). These patients most frequently had myelitis, followed by brainstem syndrome. Of the MOG-IgA patients who had MS, 38% had type-II oligoclonal bands, which was decreased when compared to MS patients without MOG-IgA. This shows that MOG-IgA patients have a specific clinical phenotype that overlaps with NMOSD. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

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