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AAN 2024 | History of investigations into the pathophysiology of FND

Mark Hallett, MD, from the National Institutes of Health, Bethesda, MD outlines challenges in the understanding and treatment of functional neurological disorder (FND) at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO. He explains that FND has been recognized using differing terminology throughout history and highlights the historical challenges involved in understanding the pathophysiology of FND, particularly through the work of Jean-Martin Charcot. Charcot, best known for his work defining multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) struggled to identify the clinicopathological correlation in FND and understood associated pathologies to be ‘dynamic lesions’. Advances have since been made through the development of new techniques to identify the pathophysiology associated with FND.

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