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ECTRIMS 2023 | Unlocking clinical potential: autoantibody detection and antigen discovery

Amandine Mathias, PhD, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, discusses a project, currently in its early stages, that centers on identifying specific autoantibodies in patients with CNS disorders. With a cohort of fewer than 200 patients, the research aims to pinpoint promising candidates with a high likelihood of autoantibody presence. Once specific autoantibodies are detected, the next step involves antigen discovery. After identifying a CNS antigen, its expression can be enhanced within a cell line, creating a diagnostic tool that can assess the antibody’s presence in a broader patient group. This process is not just diagnostic; if an antibody targets a surface antigen, it can inform therapeutic strategies and potential immunotherapies. This method offers clinicians a refined approach to patient care. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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