AAN 2026 | Multimodality risk scoring system to predict vascular events in patients with migraine

Yes, so patients with migraine are at higher risk for vascular outcomes compared to general population. However, there hasn’t been many research comprehensively done in this area. So the goal of our project was to create a risk scoring system specifically for patients with migraine, hopefully predicting vascular outcomes in their future. We have done three separate analysis focusing on vascular outcomes in the past. The first one was electrocardiogram features that were predictive of vascular outcomes. The second one was echocardiography features. There were several structural abnormalities seen in patients with migraine that are associated with vascular outcomes. And the third one was migraine, very detailed headache characteristics that are predictive, again, for vascular outcomes. And we combined these three separate analyses into one scoring system, and we also considered demographics and comorbidities and created a scoring system. We had about 300 patients in our final analysis, and the optimal cutoff for their scoring system was 15. And for patients who are in the high-risk scores group, they had significantly shorter vascular event-free survival, and the hazard ratio was 3.83. And because our analysis included a very small sample size in the last stage and we didn’t have external validation yet so absolutely future studies are necessary to validate those outcomes. However, this study is a very first attempt to create vascular scoring system specifically for patients with migraine and we are hopeful that future studies can use our data as an informative tool for vascular outcomes.

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