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EHC 2022 | How to sequentially try all possible “pick two” combinations of abortive/prevention medications?

In certain situations, combining medications for the treatment of headache is inevitable. However, switching multiple medications together may expose patients to unwanted side effects and introduce confusion in determining the efficacies of individual drugs. Pengfei Zhang, MD, Robert Wood Johnson University Hospital, New Brunswick, NJ, describes a project aimed at understanding if it is possible to try all potential “”pick two”” combinations of abortive/preventives while adjusting only one medication at a time. This project used the concept of Hamiltonian paths and showed that it is possible to try all possible non-interacting “”pick two”” medication combinations by adjusting only one medication at a time. This interview took place at the 16th European Headache Congress (EHC) in Vienna, Austria.

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