ESOC 2026 | The need for further research to understand the pathophysiology of mixed location hemorrhages
João Pinho, MD, RWTH Aachen University, Aachen, Germany, discusses the various causes of intracerebral hemorrhage and highlights the need to better understand the pathophysiology of mixed location hemorrhages. Dr Pinho notes that these patients likely have a lower burden of amyloid pathology, but further research is needed to better understand this group. This interview took place at the 12th European Stroke Organisation Conference (ESOC) in Maastricht, The Netherlands.
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Transcript
Intracerebral hemorrhage has many causes and one of the most frequent causes is atrial sclerotic small vessel disease which is related to vascular risk factors but also cerebral amyloid angiopathy is another important cause for intracerebral hemorrhage. We know that there are some patients who have a mixed pattern of hemorrhagic lesions that we can see in the MRI. And we are not sure what this mixed pattern of hemorrhagic lesions in the MRI means...
Intracerebral hemorrhage has many causes and one of the most frequent causes is atrial sclerotic small vessel disease which is related to vascular risk factors but also cerebral amyloid angiopathy is another important cause for intracerebral hemorrhage. We know that there are some patients who have a mixed pattern of hemorrhagic lesions that we can see in the MRI. And we are not sure what this mixed pattern of hemorrhagic lesions in the MRI means. These patients appear to have characteristics that are somewhat overlapping with patients with cerebral amyloid angiopathy and some other characteristics appear to overlap with patients who have arteriosclerotic small vessel disease. And this group of patients are called the mixed location hemorrhage patients. They are a relatively poorly studied group of patients and we need to know more about them. It is already known that they probably have a lower burden of amyloid pathology but more studies are needed to understand better this group.
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