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AD/PD 2024 | NfL shows strong prognostic value in pre-manifest Huntington’s disease

Natalia E. Owen, MPhil Candidate, University of Cambridge, Cambridge, UK, discusses her study looking at the comparative prognostic potential of various fluid biomarkers in Huntington’s disease (HD). Neurofilament light (NFL), GFAP, and total tau were compared head-to-head in a 14-year serial longitudinal investigation, which followed patients in the late pre-manifest transitional phase. NfL showed exciting results, with levels being higher in converters than in non-converters and controls at every time point. The rate of change in NfL was also higher in converters and a higher rate was predictive of greater deficits at the final assessment. GFAP and tau did not show significant difference between groups and did not correlate with clinical outcomes. These findings suggest that NfL is of significant prognostic value in the pre-manifest stages of HD. This interview took place at the AD/PD™ 2024 congress in Lisbon, Portugal.

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