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ESOC 2023 | INTERACT3 helps to bridge the evidence-practice gap in intracerebral hemorrhage

INTERACT3 (NCT03209258), the largest clinical trial on intracerebral hemorrhage (ICH), has the potential to change clinical practice, having demonstrated a statistically significant improvement in functional outcomes with the use of a goal-directed care bundle for rapid correction of abnormal physiological variables, compared to usual care. Craig Anderson, PhD, from The George Institute for Global Health, describes how INTERACT3 studied patients with varying degrees of stroke severity, including those traditionally difficult to recruit due to their critical condition and high priority for surgery. This diversity in patient selection makes the trial’s results highly generalizable. The trial focuses on implementing changes in care systems, bridging the evidence-practice gap. It addressed critical aspects such as funding, training, and logistical considerations, making it more practical to adopt and sustain the care bundle protocol in a healthcare setting. Formative interviews with healthcare providers participating in the intervention rollout were conducted to assess successes and challenges, helping to ensure INTERACT3’s effectiveness. This interview took place at The European Stroke Organisation Conference 2023 in Munich, Germany.

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Craig Anderson reports the following disclosures: I have received grant monies paid to my institution from the National Health and Medical Research Council (NHMRC) of Australia, the Medical Research Council (MRC) of the UK, Takeda, Penumbra, and Credit pharma. I have leadership positions as Editor-in-Chief of Cerebrovascular Diseases journal and am Vice-President of the World Stroke Organisation.