ECTRIMS 2023 | Predicting MS progression

Burcu Zeydan, MD, Mayo Clinic, Rochester, MN, explores key prognostic factors for multiple sclerosis (MS). Numerous markers can be studied to given information on MS disease course, including demographic features like age, sex, ethnicity, and co-morbidities such as diabetes and anxiety, as well as clinical features, radiological features, and laboratory biomarkers. These factors focus on predicting two main outcomes: the conversion of clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) to clinically definite MS and disability worsening. Factors predicting the transition from CIS to MS include younger age at onset, high T2 lesion burden, and the presence of CSF oligoclonal bands. For the transition from RIS to MS, predictive factors include younger age at onset, male gender, spinal cord and infratentorial lesions, along with the presence of CSF oligoclonal bands. These prognostic factors play a crucial role in informing a tailored treatment approach, enhancing the effectiveness of MS management. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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