My work in Oxford is dedicated to MMN, so Multifocal Motor Neuropathy, where basically I try to find out the origin of the disease. So this MMN is caused by an antibody, an IgM monoclonal antibody called GM1. And basically we know that this GM1 is deleterious for the nerves, but we don’t know where it comes from. So basically my aim is to pinpoint the B cells, so the lymphocytes that are creating, that are secreting this antibody...
My work in Oxford is dedicated to MMN, so Multifocal Motor Neuropathy, where basically I try to find out the origin of the disease. So this MMN is caused by an antibody, an IgM monoclonal antibody called GM1. And basically we know that this GM1 is deleterious for the nerves, but we don’t know where it comes from. So basically my aim is to pinpoint the B cells, so the lymphocytes that are creating, that are secreting this antibody. And we were able to basically sequence the antibody of interest with all the mutation profile, et cetera. And so we can now use that, clone it, and test it on iPSC. So it’s like nerves that are done in vitro, if you want. And we can test it on this iPSC to see how it affects the nerve and how deleterious it is for the nerve and based on that we can now design eventually more targeted therapies so that’s basically the aim of the project.
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