ACTRIMS 2024 | Comparing cognitive profiles in multiple sclerosis vs. Alzheimer’s disease

Cognitive impairment is prevalent in both multiple sclerosis (MS) and Alzheimer’s disease (AD), yet little data exist on their comparative cognitive profiles. In a video discussion, Le Hua, MD, FAAN, and Laura Hancock, PhD, from the Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, present findings from a retrospective study examining cognitive profiles in older patients with these conditions. Results reveal varying cognitive profiles between MS and AD patients with mild impairment, but substantial overlap in severe impairment cases. This challenges the conventional notion that MS-related cognitive deficits primarily manifest as processing speed issues, while AD primarily affects memory consolidation. The study underscores the need for further research in older MS populations to elucidate the underlying biology of cognitive decline, given the increasing longevity of MS patients. This interview took place during the annual ACTRIMS Forum 2024.

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