Michael Geschwind, MD, PhD, FAAN, Memory and Aging Center, University of California, San Francisco, CA, discusses the challenges in diagnosing prion diseases, particularly the need for improved clinician education. Advanced technologies such as diffusion MRI and RT-QuIC in cerebrospinal fluid have emerged as reliable tests for the diagnosis of prion diseases. However, disease-associated MRI changes are often missed or overlooked, leading to diagnostic delays. Disease course is commonly progressed significantly by the time prion disease is considered as a diagnosis. Dr Geschwind emphasizes the need for better training for doctors to recognize these diseases earlier and improve diagnostic accuracy. This interview took place at the 18th Annual Congress on Controversies in Neurology (CONy 2024) in London, UK.
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