James Rowe, PhD, University of Cambridge, Cambridge, UK, describes the challenges that are currently faced when making a progressive tauopathy diagnosis. The first challenge Prof. Rowe identifies is the lack of confidence and education of some neurologists and physicians who are not familiar with rare tauopathies. This can result in a delayed diagnosis if the patient only displays suggestive characteristics. The development of biomarkers to allow for testing will also improve diagnostic confidence. The second challenge is to broaden neurologists and physicians’ understanding of what could be a progressive tauopathy. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).