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ISC 2024 | The impact of the neurovasculome on cognitive function in neurodegenerative diseases

Costantino Iadecola, MD, Weill Cornell Medical College, Cornell University, New York, NY, explains the intricate relationship between the neurovasculome and cognitive function. Prof. Iadecola emphasizes that data from single-cell studies in the Alzheimer’s disease (AD) brain versus the healthy brain reveal that approximately ⅔ of AD risk genes are vascular genes, strongly indicative of a neurovascular component underlying cognitive decline. The neurovasculome contributes to both the production and clearance of proteins like amyloid β (Aβ) and tau. For example, hypertension is thought to provoke amyloidogenic processing and impact tau phosphorylation, leading to protein accumulation. On the other hand, impaired vascular function can hinder the brain’s waste clearance mechanisms. Therefore, the disruption of the neurovasculome causes a number of pathogenic mechanisms that contribute to cognitive dysfunction in neurodegenerative diseases. This interview took place during the International Stroke Conference 2024 in Phoenix, AZ.

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