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K. Ray-Chaudhuri, FRCP (Lond), FRCP (Edin), MD, DSc, King’s College London, London, UK, gives an overview of the most pressing unmet needs in Parkinson’s disease, including slowing of disease progression/neuroprotection and more effective treatment of non-motor symptoms. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).