Claudia Trenkwalder, MD, University Medical Center of Göttingen, Göttingen, Germany, talks about the management of augmentation in restless legs syndrome (RLS). Prof. Trenkwalder first focuses on the challenges of managing augmentation, which often requires clinicians to reduce the dose of dopaminergic medication prescribed. Prof. Trenkwalder then discusses other medications that may benefit patients with sleeping disorders, including opioids and short-acting benzodiazepines. To conclude, Prof. Trenkwalder emphasizes the benefits of using an opioid-based regimen for augmentation, although clinical trials are needed to investigate this further. This interview took place during the World Sleep Congress 2022 in Rome, Italy.