Rhonda Voskuhl, MD, University of California, Los Angeles, CA, discusses the impact of age and menopause on multiple sclerosis (MS). Age has long been associated with brain atrophy and neurodegeneration and is the most important risk factor for neurodegenerative diseases. Some aspects of brain aging in women may be caused by menopause, indicated by its association with cognitive difficulties in healthy women. Since disability worsening is reported in menopausal women with MS, understanding its effects on cognition and brain atrophy in healthy women is important to provide insights into its effects in MS. This interview took place during the ACTRIMS Forum 2021.