EAN 2025 | Measuring CGRP levels in the tear fluid of migraine patients: a novel, non-invasive technique
Marina Romozzi, MD, PhD(c), Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy, discusses a study that measured calcitonin gene-related peptide (CGRP) levels in the tear fluid of patients with migraine, and the effect of anti-CGRP monoclonal antibodies. Dr Romozzi reports findings from the study, which support this novel non-invasive method for detecting CGRP levels in migraine. This interview took place at the 11th Congress of the European Academy of Neurology (EAN 2025) in Helsinki, Finland.
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Transcript
In this study we measured CGRP levels in the tear fluid of patients with migraine compared to healthy controls and also as a proof of concept part we measured CGRP in tear fluid pre and post treatment with monoclonal antibodies, anti-CGRP ligand. And this was a cross-sectional study in which we included consecutive patients with a diagnosis of migraine with and without aura, and we included 76 subjects, in particular 52 patients with migraine and 24 healthy controls...
In this study we measured CGRP levels in the tear fluid of patients with migraine compared to healthy controls and also as a proof of concept part we measured CGRP in tear fluid pre and post treatment with monoclonal antibodies, anti-CGRP ligand. And this was a cross-sectional study in which we included consecutive patients with a diagnosis of migraine with and without aura, and we included 76 subjects, in particular 52 patients with migraine and 24 healthy controls. And we found significantly elevated levels of CGRP in the tear fluid of patients with migraine compared to healthy controls. We also found higher levels of CGRP in the tear fluid in patients with aura versus without aura and also we found significantly higher levels in patients assessed in the ictal phase compared to the interictal phase. So we measured for the first time CGRP in the tear fluid using a novel technique. In particular, we collected the tear fluid with the Schirmer strips, which is a completely non-invasive method. And we really suggest for future directions that these non-invasive sources for detecting CGRP in migraines should be explored.
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