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AAN 2025 | Holmes tremor and how it can present as an atypical sign of intracranial hypotension

Muhammad Yousaf, MD, Virginia Tech Carilion School of Medicine, Roanoke, VA, discusses a case of a patient with Holmes tremor as an atypical presentation of intracranial hypotension. The patient presented with subacute right vision loss and an olfactory groove meningioma. The patient’s tremors did not improve with medications such as sodium channel blockers, but conservative management with hydration led to a significant improvement in symptoms. This interview took place at the 77th American Academy of Neurology (AAN) Annual Meeting in San Diego, CA.

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Transcript

So we had a case of a patient who was coming with subacute right vision loss and then further during his workup we did find he had an olfactory groove meningioma grade one. Little about Holmes tremor is that it’s as we know also called rubral tremor of varying amplitude low frequency two to 5 hertz, intentional postural and kinetic tremor. So that was one of the differential diagnoses, but obviously, focal seizures could not be ruled out as well...

So we had a case of a patient who was coming with subacute right vision loss and then further during his workup we did find he had an olfactory groove meningioma grade one. Little about Holmes tremor is that it’s as we know also called rubral tremor of varying amplitude low frequency two to 5 hertz, intentional postural and kinetic tremor. So that was one of the differential diagnoses, but obviously, focal seizures could not be ruled out as well. So we got an EEG on him, which was a normal study. We did try sodium channel blockers, SV2 inhibitors, and also gabaergic medication, but it did not help him. So we got an MRI, and MRI was classic for intracranial hypotension signs, which was, again, the sagging of the brain, dural enhancement could be seen. For that patient, we did do conservative management, especially with hydration, and we did follow up three months later, which really was a drastic change when we saw him. His tremors had improved and at the same time, his MRI also resolved.

 

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