EAN 2024 | Similarities between CIDP and MS and NMOSD

Alicja Kalinowska, MD, PhD, Poznan University of Medical Sciences, Poznań, Poland, outlines the overlap in immunopathology between chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). CIDP and MS have a large overlap in underlying immune involvement; both are forms of macrophage-mediated demyelination. In MS, this affects the central nervous system, whereas in CIDP the peripheral nervous system is affected. Immune dysregulation is a main component of pathophysiology of these diseases, including profound T- and B-cell involvement and issues with the blood-brain/blood-nerve barrier. Complement activation is a feature shared between CIDP and NMOSD, as well as type II immunopattern lesions in MS. These similarities mean that a multitude of MS and NMOSD drugs could be repurposed for CIDP. This interview took place at the European Academy of Neurology (EAN) Annual Meeting 2024 in Helsinki, Finland.

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