Kristen Krysko, MD, University of California San Francisco, San Francisco, CA, comments on how pregnancy can reduce the severity of multiple sclerosis. Hormonal fluctuations that occur during pregnancy such as changes in estriol and progesterone levels have found to have a protective effect in mothers against MS. Whilst the exact hormone causing this is unknown, breastfeeding additionally has a similar modulating effect in women. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.