ACTRIMS 2022 | Clinical and radiological features of NMOSD

Amy Kunchok, MD, Cleveland Clinic, Cleveland, OH, provides an overview of the characteristic clinical and radiological features of neuromyelitis optica spectrum disorder (NMOSD). Optic neuritis is typically bilateral and often involves the posterior of the optic nerve. This contrasts with multiple sclerosis (MS), which is usually a unilateral optic neuritis, or MOG antibody disease, which is often an anterior segment optic neuritis. Longitudinally extensive transverse myelitis is typical of NMOSD, meaning myelitis greater than three vertebral segments in length. Dr Kunchok also outlines MRI brain lesion patterns commonly seen in NMOSD and how they can be used in differentiating from MS. This interview took place at the ACTRIMS Forum 2022 in West Palm Beach, Florida.