Rejko Krüger, MD, University of Luxembourg, Belvaux, Luxembourg, shares the findings of a study investigating gut microbial changes associated with Parkinson’s disease (PD). The study focused on patients followed in the Luxembourg Parkinson’s Disease Study as well as age/sex-matched healthy control subjects. Results show that specific microbiota species were overrepresented while others were underrepresented in PD patients. Additionally, metabolic modeling of the gut microbiomes revealed altered metabolite secretion potentials, particularly for sulfur metabolism. The analysis also identified that the abundance of certain bacteria species was associated with disease progression. This interview took place during the AD/PD™ 2021 conference.