Sleep Europe 2026 | 24-hour heart rate as a biomarker of hyperarousal in insomnia: a real-world daridorexant study

Alessandro Colitta, MD, University of Pisa, Pisa, Italy, discusses a real-world exploratory study investigating whether 24-hour heart rate oscillations could be a reliable biomarker of self-reported hyperarousal in patients with chronic insomnia, using daridorexant as a proof of concept. Dr Colitta explains that hyperarousal modulated the amplitude and phase of 24-hour heart rate oscillations, as did daridorexant. Although the sample size was limited, patients with higher pre-sleep arousal appeared most likely to benefit from treatment. This interview took place at Sleep Europe 2026 in Maastricht, the Netherlands.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.