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SLEEP 2026 | Stimulus control and sleep restriction therapy: reprogramming the brain to treat insomnia

Michael Grandner, PhD, University of Arizona, Tucson, AZ, discusses the role of conditioned arousal in chronic insomnia and explains why behavioral approaches such as stimulus control and sleep restriction therapy remain the cornerstone of treatment. He reviews key principles of cognitive behavioral therapy for insomnia (CBT-I) and highlights how these strategies can help patients retrain sleep-related behaviors and achieve long-term improvements. This interview took place at the 40th annual meeting of the Associated Professional Sleep Societies (APSS) in Baltimore, MD.

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Transcript

So treating insomnia, especially treating chronic insomnia, the methods that you want to use focus on the issue of conditioned arousal. What happens with chronic insomnia is that what starts as a sleep problem becomes predictable. Sleep starts becoming predictably stressful. And that predictable stress becomes a little bit of anticipation and worry about not sleeping. You get into bed worried a little bit that you might not be sleeping...

So treating insomnia, especially treating chronic insomnia, the methods that you want to use focus on the issue of conditioned arousal. What happens with chronic insomnia is that what starts as a sleep problem becomes predictable. Sleep starts becoming predictably stressful. And that predictable stress becomes a little bit of anticipation and worry about not sleeping. You get into bed worried a little bit that you might not be sleeping. But that increases the level of activation in your mind and your body, which makes it just a little bit harder to fall asleep or stay asleep when you wake up. And so then that actually strengthens the relationship between sleep and stress and pairs them together because they become a stronger pair, which then makes you anticipate and fear sleep a little bit, which then increases that activation, which makes it harder to sleep, which then then increases the pairing and it becomes this cycle that just feeds forward. And so whatever caused the initial insomnia isn’t even really always in the picture anymore it’s this it’s this cycle of worrying about sleep which increases activation which makes sleep harder which then makes you worry about sleep and so the answer and most effective way, and there’s decades of data that show this, the most effective way to fix chronic insomnia is actually to reprogram the brain and help it relearn how to sleep. And stimulus control and sleep restriction therapy are two of the most effective ways to do it. Now, sleep restriction therapy is tricky because sometimes it can be rather extreme and you really need someone who knows what they’re doing to oversee it. It’s not something I’d recommend people do on their own. And in terms of helping with it, if you have a therapist who is helping walking you through sleep restriction therapy and you’re feeling worse at first, that might be part of the process because part of what sleep restriction therapy does is it drives up your natural sleep drive enough to kind of overpower whatever those mental blocks are. But that’s why you need a trained therapist to help make sure you’re still staying safe and within the boundaries of what’s working. And you don’t get frustrated. Once you start it, you kind of have to power through or else it’s not going to be as helpful. But for that one, I think it’s more about getting someone who knows what they’re doing to help you. Stimulus control, that’s another one where it’s extremely effective. What stimulus control is, it’s in a nutshell, it’s gaining control over what the bed is a stimulus for. Is it a stimulus for sleep or is it a stimulus for wake and worrying? And for a lot of people, the bed becomes the place where you’re not asleep. It becomes the place where sleep is not predictably going to happen. And you want bed to equal sleep. And if you can control the bed side of the equation, but not the sleep side of the equation, that’s where you start. If you want bed to equal sleep, and right now bed does not equal sleep, you’ve got to get yourself out of bed. Not bed needs to be not sleep. So what that means is if you’re in bed and sleep isn’t coming, don’t be there. You can’t make yourself hungry. You can’t speed up your own metabolism. You can’t make yourself sleepy. If there’s something outside of your control preventing you from sleeping, fighting it isn’t going to make you fall asleep faster. The trick is let your natural process start working the way it wants, and it will get better, but it takes time. People will say things like, well, I tried getting out of bed, but it didn’t make me fall back asleep any faster. Well, it’s not going to tonight. Getting out of bed doesn’t make you sleepy. What getting out of bed does is it slightly weakens the bed equals wake connection. And if you do that enough and reliably over time, and you only are in bed when you’re sleeping, it strengthens that bed sleep connection. It’s a slow process. It’s a gradual process. And when people get frustrated, it’s because they feel like it’s not working fast enough. And again, this is why sometimes you need an experienced therapist or somebody who knows what they’re doing to help coach you and guide you through the process to make sure you’re on track, because sometimes it might feel like it’s not working. But if you look at your data, you’ll actually notice you’re going in the right direction, just a little slower than you think, but slower and steady. And that’s why when most people finish these sort of behavioral procedures for insomnia, this brain retraining, and it’s part of CBTI, cognitive behavior therapy for insomnia, when people go through it, often they never have to get treatment for insomnia again. Because not only does it last because you’ve rewired the process, but you also know what to do when you have new problems arise.

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Disclosures

Grant: Harmony Biosciences, Consultation: Google, Natrol, Haleon, Kenvue, Smartypants Vitamins, ResMed.