AD/PD 2026 | The PI‑2620 tau-PET tracer to detect tau pathology or co-pathology in neurodegenerative diseases
Saul Martinez-Horta, MD, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, discusses the PI‑2620 tau-PET tracer, which is used to detect tau pathology or co-pathology in various neurodegenerative diseases. Dr Martinez-Horta highlights that this tracer can differentiate between specific isoforms of tau species in the brain, allowing for the inference of four-repeat or three-repeat tau pathology. This interview took place at the AD/PD™ 2026 International Conference on Alzheimer’s and Parkinson’s Diseases in Copenhagen, Denmark.
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Transcript
Well, this is a super interesting second-generation tau PET tracer that allows us to investigate in vivo tau binding activity. It means that it allows us to see if there is tau pathology or tau co-pathology in association with several neurodegenerative diseases. And this is extremely interesting because depending on the time window of the acquisition you are using when using this tau PET tracer, you can also infer the specific isoform of tau species in the brain...
Well, this is a super interesting second-generation tau PET tracer that allows us to investigate in vivo tau binding activity. It means that it allows us to see if there is tau pathology or tau co-pathology in association with several neurodegenerative diseases. And this is extremely interesting because depending on the time window of the acquisition you are using when using this tau PET tracer, you can also infer the specific isoform of tau species in the brain. It means that you can infer if this activity or this binding of the PET activity is related to four-repeat tau pathology or it’s more related to three-repeat tau pathology. So in several neurodegenerative diseases where the existence of tau-mediated pathology is not something evident in people who are still alive because they are young, etc. This is the best way to look at the possibility of these patterns of co-pathology mediated by tau in these brains with which kind of isoforms.
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